Nutrition Health Review

FALL 2017

Nutrition Health Review provides consumers updates on the latest medical research, news, trends, and products in nutrition and healthy living.

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13 Fall 2017 • Volume 117 NutriƟon Facts and Supplement Science for Managing AuƟsm S pecific diets for children with auƟsm have been found in many studies to improve their symptoms. In one study, 387 parents/primary caretakers completed a 90-item quesƟonnaire about the children's gastrointesƟnal (GI) symptoms, food allergies, food sensiƟviƟes, and diet. Results found that a specialized diet for children with auƟsm who had GI symptoms and food allergies/sensiƟviƟes led to improvement in auƟsm spectrum disorder (ASD) behaviors of the children, compared to those with none of those symptoms. ImplemenƟng a strict diet that removed gluten and casein also resulted in an improvement in symptoms. Overall, the study suggests that GI and immune factors could impact how children with ASD react to diet implementaƟons. A study done in Poland aimed to measure how diet and dietary supplements could impact people with ASD. The diet of a person with ASD is going to vary depending on the person's other symptoms; this study called for constant assessment of the person's diet to make sure it was tailored for his or her unique situaƟon. It also notes that while a specific diet can help with symptoms of ASD and possibly prevent the occurrence of gastrointesƟnal disorders, diet alone will not be able to effecƟvely treat ASD alone. Omega-3 faƩy acids, probioƟcs, vitamins, and minerals are important areas of focus for research regarding the diet of someone with ASD. Further, a randomized, double-blind, placebo- controlled study with 141 people with ASD found that a special mulƟvitamin, which contained ingredients such as CoQ10, MSM, and N-acetylcysteine, was able to improve ASD symptoms, such as hyperacƟvity and tantrums. MulƟple studies have also found that melatonin supplementaƟon can help—many children with auƟsm are reported to have lower levels of melatonin and subsequent trouble falling asleep. ProbioƟcs have been shown to improve GI issues from which people with ASD oŌen suffer. Other studies have confirmed that omega-3 faƩy acids and vitamin C have helped improve symptoms, as well. Sources 1. Klein L, Pennesi CM. EffecƟveness of the gluten- free, casein-free diet for children diagnosed with auƟsm spectrum disorder: Based on parental report. NutriƟonal Neuroscience. 2012 Mar;15(2):85– 91. 2. Kawicka A, Regulska-Ilow B. How nutriƟonal status, diet and dietary supplements can affect auƟsm. A review. Rocz Panstw Zakl Hig. 2013;64(1):1– 12. 3. Which supplements have been shown to be helpful for auƟsm? August 2017. Consumer Labs. hƩps://www.consumerlab.com/answers/which-supplements- have-been-shown-to-be-helpful-for-auƟsm/supplements_for_auƟsm/ to a placebo. 17 Another study that evaluated 33 paƟents with degeneraƟve Alzheimer's who took 300mg of phosphaƟdylserine for eight weeks showed an increase in overall wellbeing but did not display any differences in cogniƟve funcƟon tests. 18 Sources 1) Tan MS, et al. Efficacy and adverse effects of ginkgo biloba for cogniƟve impairment and demenƟa: a systemaƟc review and meta-analysis. J Alzheimer's Dis. 2015;43(2):589– 603; 2) Laws KR et al. Is Ginkgo biloba a cogniƟve enhancer in healthy individuals? A meta-analysis. Hum Psychopharmacol. 2012 Nov;27(6):527–33; 3) DeKosky S, et al. Ginkgo biloba for prevenƟon of demenƟa: a randomized controlled trial. JAMA. 2008 Nov 19; 300(19): 2253–2262; 4) Alpha lipoic acid. July 10, 2016. Alzheimer's Drug Discovery FoundaƟon. hƩps://www.alzdiscovery.org/cogniƟve-vitality/raƟngs/alpha- lipoic-acid - ref-6. Accessed Dec 12 2017; 5) Vidović B, et al. Effect of alpha-lipoic acid supplementaƟon on oxidaƟve stress markers and anƟoxidaƟve defense in paƟents with schizophrenia. Psychiatr Danub. 2014 Sep;26(3):205–13; 6) Shinto L, et al. A randomized placebo-controlled pilot trial of omega-3 faƩy acids and alpha lipoic acid in Alzheimer's disease. J Alzheimer's Dis. 2014;38(1):111–20; 7) Fava A, et al. The effect of lipoic acid therapy on cogniƟve funcƟoning in paƟents with Alzheimer's disease. J Neurodegener Dis. 2013;2013:454253; 8) Robinson JG, et al. Omega-3 faƩy acids and cogniƟve funcƟon in women. Womens Health (Lond Engl). 2010 Jan; 6(1): 119–134; 9) Bauer I, et al. Omega-3 supplementaƟon improves cogniƟon and modifies brain acƟvaƟon in young adults. Hum Psychopharmacol. 2014 Mar;29(2):133–44; 10) Conquer JA, et al. FaƩy acid analysis of blood plasma of paƟents with Alzheimer's disease, other types of demenƟa, and cogniƟve impairment. Lipids. 2000 Dec;35(12):1305–12. 11) Acetyl-L-carniƟne. Altern Med Rev. 1999 Dec;4(6):438–41; 12) Rai G, et al. Double-blind, placebo controlled study of acetyl-l-carniƟne in paƟents with Alzheimer's demenƟa. Curr Med Res Opin. 1990;11(10):638–47; 13) Age-Related CogniƟve Decline (HolisƟc). 2017. University of Michigan Medicine.hƩp://www.uofmhealth.org/health-library/ hn-1011007#hn-1011007-supplements. Accessed Dec 12 2017; 14) Yang X, et al. NeuroprotecƟon of Coenzyme Q10 in NeurodegeneraƟve Diseases. Curr Top Med Chem. 2016;16(8):858–66; 15) Li Z, et al. The effect of creaƟne and coenzyme q10 combinaƟon therapy on mild cogniƟve impairment in Parkinson's disease. Eur Neurol. 2015;73(3-4):205–11; 16) Yamagishi K. Serum coenzyme Q10 and risk of disabling demenƟa: the Circulatory Risk in CommuniƟes Study (CIRCS). Atherosclerosis. 2014 Dec;237(2):400–3; 17) Crook T, et al. Effects of phosphaƟdylserine in Alzheimer's disease. Psychopharmacol Bull. 1992;28(1):61–6; 18) Engel RR, et al. Double-blind cross-over study of phosphaƟdylserine vs. placebo in paƟents with early demenƟa of the Alzheimer type. Eur Neuropsychopharmacol. 1992 Jun;2(2):149–55.

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