Nutrition Health Review

Summer 2017

Nutrition Health Review provides consumers updates on the latest medical research, news, trends, and products in nutrition and healthy living.

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Summer 2017 • Volume 116 5 Radiopharmaceuticals, found that v itamin C helped prevent UV- induced cell death in skin cancer cells. 10 Even though topical vitamin C is where most of the benefits lie for skin health, ingested vitamin C is one of the safest and most effective nutrients you can put in your body. 1 1 Benefits include immunologic surveillance as well as protection against cardiovascular disease, prenatal health problems, and eye disease. Oranges, grapefruit, and pineapples are great sources of vitamin C, as are red, yellow, and green peppers, papaya, kiwi, and guava. Did you know that guava has more vitamin C than any other fruit or vegetable? VitamiN E Vitamin E has been shown to prevent wrinkles and improve the texture and elasticity of your skin. It also prevents UV radiation damage, making vitamin E especially important during the warm months when you are exposed to the sun for longer periods of time. One study reported that having the correct intake of vitamin E (as well as vitamin A) reduces oxidative stress (an imbalance between the production of free radicals and the ability of the body to counteract or detoxify their harmful effects through neutralization by antioxidants) and improves skin quality. 1 2 A meta-analysis from the Journal of Cosmetic Dermatology reported that topical vitamin E is effective in reducing erythema, sunburn cells, and photocarcinogenesis, and that high doses of oral vitamin E reduce chronic UV-B-induced skin damage. 13 Another study, published in the Journal of American Academy of Dermatology, revealed that a topical combination of vitamins C and E achieved significant photoprotection of the skin. 14 Unlike some of the other vitamins, you won't find a single food that contains 100 percent of the recommended daily allowance of vitamin E. However, there is a variety of foods that can give you a good start in reaching the recommended daily allowance, including almonds, spinach, sunflower seeds, and sweet potato. Palm oil and olive oil also contain Vitamin E, and are in a variety of products and can be used in cooking. SElENium There is conflicting research on the impact selenium has on preventing skin cancer, but there is research that suggests it might have a positive effect. 15 A 1996 study, published in the Journal of the American Medical Association, is one of the original studies that prompted positive discussion over the mineral's health impact. 16 While selenium treatment did not protect against development of basal or squamous cell carcinomas of the skin, results from this study did suggest that supplemental selenium might reduce the incidence of, and mortality from, carcinomas in several other sites of the body. Scientists Find Protein that Regulates Skin Cancer Spread by NHR Staff S cientists have pinpointed a cancer protein that controls the disease's spread from the skin to other organs. In a study recently published in Nature, researchers propose that blocking this cancer protein may be an effective treatment. Working with mice genetically engineered to develop human skin cancers, the team discovered that the protein plays a key role promoting—or inhibiting—metastasis, the spread of cancer from one area or organ to another. Dubbed MIDKINE, the protein is secreted by melanomas—the most serious type of skin cancer—before traveling to a different part of the mouse body to kickstart cancer formation, researchers said. In subsequent observations in humans, high levels of MIDKINE in the lymph nodes of skin cancer patients were predictive of "significantly worse" outcomes, the research team reported. "When these tumors are aggressive, they act at a distance much earlier than previously thought," said the authors. MIDKINE traveled directly to the new cancer site irrespective of lymph vessel formation around the original tumors. When MIDKINE was inhibited in mouse tumors, metastasis was blocked as well, said the team. "These results indicate a change of paradigm in the study of melanoma metastasis," the researchers say. SOURCES: 1) NewsMaxHealth. Health-News Health-disease-cancer-science/2017/06/29/id/ 798905/. Accessed Sep 13, 2017; 2) Olmeda et al. Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine. Nature. 2017;546:676–680. NHR Guava is an excellent source of vitamin C.

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